Influences of Oestrogen on Neurodegneration and Behaviours

Estrogens do not protect, but androgens exacerbate, collagen accumulation in the female mouse kidney after ureteric obstruction

TD Hewitson, WC Boon, ER Simpson, ER Smith, CS Samuel

2016-08-01

Aims Controversy surrounds the gender basis of progression in chronic kidney disease. Unfortunately, most experimental studies add..

Relaxin and castration in male mice protect from, but testosterone exacerbates, age-related cardiac and renal fibrosis, whereas estrogens are an independent determinant of organ size

TD Hewitson, C Zhao, B Wigg, SW Lee, ER Simpson, WC Boon, CS Samuel

2012-01-01

This study determined the effects of castration and hormone replacement therapy on the age-related cardiac and renal pathology of ..

Aromatase and its inhibition in behaviour, obsessive compulsive disorder and parkinsonism

WC Boon, MK Horne

2011-07-01

Oestrogens regulate normal behaviour and have been implicated in modulating pathological behaviour such as obsessive compulsive di..

Behavioural phenotype of APPC100.V717F transgenic mice over-expressing a mutant Aβ-bearing fragment is associated with reduced NMDA receptor density

WC Boon, M van den Buuse, N Wegener, S Martin, HK Chua, AI Bush, CL Masters, PA Adlard, QX Li

2010-05-01

The aim of this study was to characterize APPC100.V717F transgenic (TgC100.V717F) mice which over-express a mutant C100 fragment o..